The effect of neonatal Handling on the learned helplessness model of depression.

Researchers examined the effects of neonatal handling on learned helplessness (LH) in rats.  They discuss prior research that showed a variety of benefits associated with neonatal handling such as improved escape latency and lower emotional reactivity.  They express that rats who have been handled have a permanent augmentation of the glucocorticoid receptors in their hippocampi. …